With genome assembly becoming relatively straightforward and affordable, the biggest challenge for conducting evolutionary and functional analyses with a new genome is annotating that genome. There are many different tools to choose from, but … given that most past performance assessments (or descriptions of new annotation methods) have only been tested on a few (mostly model) organisms, it is difficult to know whether a method will work well for “my genome.” To being tackling that problem, we evaluated the performance of several genome annotation methods across 21 species spanning a large swath of the tree of life. The results of this project have turned into a manuscript that is now available on bioRxiv at: https://www.biorxiv.org/content/10.1101/2024.04.12.589245v1 . Feedback is welcome!